Press Release

For immediate release

NanoHorizons Receives 2004 Frost & Sullivan Award
for Excellence in Technology

State College, PA, May 17, 2004:

NanoHorizons, an emerging leader in nanoscale material and device technologies, is a recipient of the 2004 Frost & Sullivan Award for Excellence in Technology. This award has been presented to NanoHorizons in recognition of its innovativeness in applying the science of nanotechnology to drug discovery. The company has developed novel nanotechnology-based QuickMass targets for mass spectrometry. QuickMass targets are designed for use in applications that require the identification of small molecules, and are particularly effective in analyzing drug candidates produced by combinatorial chemistry.

QuickMass targets enable quick and precise chemical analysis of small molecules by matrix-free laser desorption mass spectrometry. Using conventional MALDI (Matrix Assisted Laser Desorption Ionization) mass spectrometers, the unique QuickMass targets produce mass spectra faster than the LC/MS technique. QuickMass targets eliminate the need for matrix compounds, normally used to facilitate laser desorption and ionization of small molecules. Since matrix compounds are not required, a clean, reproducible spectrum can be produced from samples deposited on a QuickMass target with a standard MALDI mass spectrometer. By eliminating background peaks of interfering matrix compounds, good analyses of drug candidates from combinatorial chemistry laboratories can be produced more quickly. QuickMass targets can also be used in other phases of the drug discovery process, such as ADME (Adsorption, Distribution, Metabolism, and Excretion) analyses. This technique offers an increased sample throughput and can deliver up to an 80% increase in research laboratory productivity.

QuickMass targets use a non-porous thin film surface, a direct product of NanoHorizons research into thin film nanostructures and nanodevices. The thin film in QuickMass allows laser energy to be rapidly transferred to the analyte molecules in the ionization process. The result is effective small molecule desorption, ionization and mass spectroscopy without the need for an interfering matrix. An added advantage of using this non-porous film is the avoidance of low mass contaminant trapping, which can further complicate the analysis process. These advantages are all achieved while using the same methodologies and mass spectrometry equipment as conventional MALDI.

QuickMass technology is starting to gain critical acceptance, as is exemplified by the recent announcement of collaboration between NanoHorizons and Kratos Analytical Ltd. (a wholly owned subsidiary of the Shimadzu Corporation of Kyoto, Japan). As part of this program, Kratos will present QuickMass technology to the market by strategically integrating it with its currently available mass spectrometers. This collaboration is expected to enhance Kratos/Shimadzus efforts to provide equipment and targets for diverse applications in the chemical/pharmaceutical sectors.

We are most pleased to receive this award. It recognizes our success in developing a significant breakthrough product which enables drug discovery research to be more productive and cost effective said Robert F. Burlinson, President and C.E.O. of NanoHorizons.

NanoHorizons has demonstrated the ability to successfully apply the emerging science of nanotechnology to drug discovery. The companys QuickMass technology platform avoids the encumbrances of using a matrix material while significantly reducing the time required for analysis of small drug molecules. This will, wherever used, substantially enhance the throughput of drug screening processes and ultimately help bring drugs to market faster. It is in recognition of this research excellence and business potential of the technology that NanoHorizons Inc. has been bestowed with the Frost & Sullivan Award for Excellence in Technology said Giridhar Rao, industry analyst with Frost & Sullivan.

About NanoHorizons, Inc.

NanoHorizons, Inc. was founded in 2002 with a business focus on nanotechnology applications in the drug discovery, microelectronics and health care industries. The company has licensed a comprehensive portfolio of nanotechnology Intellectual Property from the Pennsylvania State University.

The initial product offering, QuickMass matrix free laser desorption plates, addresses the need for more cost effective pharmaceutical research and increased drug discovery capacity. Additional commercial initiatives are being pursued to meet needs for fast, high-sensitivity respiration monitors as well as humidity and gas sensors. Additionally, a manufacturing process used to place high performance logic, sensors, displays, MEMS and optoelectronics on inexpensive or mechanically flexible substrates offers licensing opportunities.

For more information, visit nanohorizons.com, write to us at or contact:

Robert F. Burlinson, President and CEO
Tel:
Email:

About Frost & Sullivan

Founded in 1961, Frost & Sullivan is recognized as a global leader in growth consulting. Frost & Sullivan Awards are presented to companies that demonstrate excellence in their industry, commending the diligence, commitment, and innovative business strategies required to advance in the global marketplace. Frost & Sullivan rigorously analyzes specific criteria to determine award recipients in a vast variety of market industries and landscapes. For further information, visit www.frost.com.

Award Description

Frost & Sullivans Excellence in Technology Award is bestowed upon the company that has pioneered the development and introduction of an innovative technology into the market; a technology that has either impacted or has the potential to impact several market sectors. This award recognizes a companys successful technology development that is expected to bring significant contributions to the industry in terms of adoption, change, and competitive posture. It also recognizes the overall technical excellence of a company and its commitment towards technology innovation.